In active RA lower serum osteocalcin, which is a marker of bone formation, and higher crosslinked N-telopeptidases of type 1 collagen (NTX) and deoxypyridinoline (DPD), which are markers of bone resorption, have been found compared to controls and patients with inactive rheumatoid arthritis [50]. The gene discussed is BGLAP; the disease is rheumatoid arthritis.