Interestingly, in MSC, we found, similar to colorectal cancer stem cells, a positive relation between CD133 expression and LD accumulation In addition to their function in cellular lipid homeostasis, LD seem to protect cancer cells from reactive oxygen species toxicity [31] as well as to be relevant in the temporary sequestration of proteins such as histones, enzymes involved in purine synthesis and viral capsids [32]. Here, PROM1 is linked to cancer.