PPARGC1A and Hyperglycemia: The main findings were (i) a significant downregulation of CSE in the liver of septic mice with hyperglycemia along with (ii) apparent nuclear translocation of the CSE protein under stress conditions (iii) reduced glucose production, (iv) reduction of mitochondrial respiratory activity, and (v) a significant downregulation of PGC1α, ultimately being associated with (vi) fat accumulation in the liver.