DNMT3A and hepatocellular carcinoma: One group demonstrated that SALL3 was silenced by DNA methylation and that the protein interacts with DNA methyltransferases 3 alpha (DNMT3A) in hepatocellular carcinoma [6]; another report showed that SALL3 hypermethylation reduced the level of SALL3 mRNA in hepatocellular carcinoma [7]; and aberrant hypermethylation of SALL3 along with HPV infection was found to contribute to carcinogenesis in cervical cancer [8].