In the study, we revealed that lncRNA HOXA11-AS was involved in the NSCLC cell invasion and EMT process and knockdown of lncRNA HOXA11-AS inhibited the EMT by decreasing the expression of transcription factors ZEB1, ZEB2, Snail1, Snail2 and EMT marker N-cadherin and increased the expression of E-cadherin. The gene discussed is ZEB2; the disease is non-small cell lung carcinoma.