Moreover, knockdown of lncRNA HOXA11-AS inhibited cell invasion ability, however, co-transfected with si-HOXA11-AS and miR-200b inhibitor dismissed the effects in A549 and H1299 cells (Fig. 6a–d).Thus, these results confirmed that lncRNA HOXA11-AS promoted cell EMT and suppressed miR-200b expression by interacting with EZH2 and DNMT1 in NSCLC cells. Here, DNMT1 is linked to non-small cell lung carcinoma.