In glioma stem cells, the following ranking was observed: multifunctional epirubicin liposomes (1.37 ± 0.01) > stearyl-R8 modified epirubicin liposomes (1.26 ± 0.01) > TfR-T12 modified epirubicin liposomes (1.11 ± 0.02) > epirubicin liposomes. This evidence concerns the gene TFRC and central nervous system cancer.