The results showed the following ranking of microtubules destruction effects in brain glioma: multifunctional vinblastine liposomes ≥ stearyl-R8 modified vinblastine liposomes > TfR-T12 modified vinblastine liposomes > vinblastine liposomes > free vinblastine > multifunctional blank liposomes. Here, TFRC is linked to brain glioma.