The correlation between the Wnt5a/sFRP3 ratio and the NFAT target gene RCAN1.4 in RV myocardium from patients with end-stage DCM as well as NFAT activation by Wnt5a in cardiomyocytes from NFAT-luciferase reporter mice, suggests that Wnt5a-induced NFAT signaling could be active and involved in the pathogenesis of DCM. Here, FRZB is linked to familial dilated cardiomyopathy.