The significant pathways involve 431 candidate genes, among which fourteen genes have been collected by the Cancer Gene Census Category (CGC, http://cancer.sanger.ac.uk/census/) as known breast cancer genes (CDH11, CTNNB1, DNM2, EGFR, ERBB2, ERBB3, GOPC, GRIN2A, HNRNPA2B1, NDRG1, PICALM, STRN, TCF3, and TCF7L2). Here, PICALM is linked to breast cancer.