Moreover, it seems of interest to explore if ANDRO has any effects on the inflammasome pathway in NASH given recent evidence have linked ANDRO with Nucleotide-binding oligomerization domain leucine-rich-repeat containing receptor 3 (NLRP3) inflammasome inhibition in a mouse model of intestinal inflammation22. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatohepatitis.