In a study that assessed the usefulness of sTfR as a biomarker of iron deficiency compared with that of bone marrow staining as the gold standard, the authors concluded that sTfR, albeit not optimal, was still one of the better-performing iron-status biomarkers in high-inflammation settings (13); however, only C-reactive protein (CRP) was measured to capture inflammation. Here, TFRC is linked to Iron deficiency anemia.