sTfR was more strongly and more consistently associated with AGP than with CRP. The effect of adjusting the prevalence of iron-deficient erythropoiesis (i.e., elevated sTfR) for CRP was minimal and inconsistent across surveys and therefore not recommended. Although adjusting for malaria in addition to sTfR by using the regression approach did not significantly change the estimated prevalence of iron-deficient erythropoiesis, the authors suggest accounting for malaria on the basis of the physiologic response of this biomarker to malarial infection (5). The gene discussed is CRP; the disease is malaria.