Neurodegenerative diseases (NDs) have increasingly been linked to dysfunction of specific proteins, often unique to one disease, e.g. amyloid precursor protein (APP) to Alzheimer's disease (AD), parkin (Park) to Parkinson's disease (PD), huntingtin (HTT) to Huntington's disease (HD), and superoxide dismutase (SOD1) to amyotrophic lateral sclerosis (ALS) (Kaur et al., 2016; Lill, 2016; Nopoulos, 2016; Selkoe and Hardy, 2016). The gene discussed is HTT; the disease is amyotrophic lateral sclerosis.