An interesting site of FoxO1 expression is BAT [31], which can easily transdifferentiate into muscle and vice versa [67–70], while overexpression of a constitutively active Smoothened restricted to adipocytes has been shown to give rise to embryonic rhabdomyosarcomas (ERMS) [71] with relative high penetrance. Here, FOXO1 is linked to embryonal rhabdomyosarcoma.