A common CTTTA-pentanucleotide 3′ UTR INDEL in LEPR was associated with increased body weight in patients in the Finnish Diabetes Prevention Study [60], while another novel TAT-trinucleotide INDEL variant in the 1078Y codon of LEPR (containing a putative phosphorylation site) was not associated with obesity in Dutch Caucasians [61]. Here, LEPR is linked to obesity due to melanocortin 4 receptor deficiency.