In-depth investigation of a complex region on chromosome 8p21.2 encompassing DOCK5 which includes two VNTRs of complex sequence composition (one in 5′ UTR and another in intron 1 of DOCK5) which flank a common 3975-bp INDEL (in intron 1 of DOCK5) found a significant association of these VNTRs and INDEL with childhood and adult severe obesity [261]. The gene discussed is DOCK5; the disease is Obesity.