TNF and juvenile idiopathic arthritis: The efficacy of etanercept, a TNFα inhibitor, in daily practice for JIA was confirmed in controlled clinical trials where at least 70% of patients in all categories except RF-positive polyarthritis achieved ACR Pedi 30 and at least 40% of patients in all categories achieved ACR70 [6–8]; CHAQ scores decreased in approximately 53% of patients after 12 weeks of treatment [9], and 41.8% of patients receiving long-term therapy with etanercept (approximately 2.5 years) achieved inactive disease according to the Wallace criteria [10].