Using this approach, we have uncovered that myf5:GFP+/mylz2-mCherry-negative TPCs share similar characteristics with normal muscle satellite cells, can sustain tumor growth, and are regulated by similar molecular pathways (Chen et al., 2014; Ignatius et al., 2012; Langenau et al., 2007; reviewed in Kashi et al., 2015). Here, MYF5 is linked to neoplasm.