Dectin-1 requires interferon regulatory factor 5 (IRF5) for immune responses (del Fresno et al., 2013), and IRF5 is necessary for differentiation of M1 AT macrophages, which play a major role in obesity-induced IR (Krausgruber et al., 2011). Here, CLEC7A is linked to obesity due to melanocortin 4 receptor deficiency.