MYD88 and obesity due to melanocortin 4 receptor deficiency: This contrasts the phenotype of our and other reports of the global MyD88 KO mice (Hosoi et al., 2010; Yokoyama et al., 2012) and contrasts the findings indicating that depletion of MyD88 in myeloid cells does not protect mice from obesity-induced IR (Kubinak et al., 2015).