Finally, this work shows the involvement of TRPM4‐dependent calcium signaling in the regulation of β‐catenin and provides a framework to understand the contribution of a series of ion channels whose expression and/or function is altered in the tumor progression process (Farfariello et al., 2015; Flourakis and Prevarskaya, 2009; Prevarskaya et al., 2011). Here, TRPM4 is linked to neoplasm.