All immune cell types [including dendritic cells (DC), natural killer (NK) cells, macrophages, neutrophils, B and T lymphocytes (CD4+ T helper 1 (TH1) and 2 (TH2), CD8+ cytotoxic T cells (CTL), memory cells, and regulatory T (Treg) cells)] may be present within or at the edge of a given tumor, or in a form of tertiary lymphoid structures located in the stromal compartment that gather multiple immune components similar to that found in secondary lymphoid organs (Fridman et al., 2012). This evidence concerns the gene CD8A and neoplasm.