KLRK1 and cancer: There is also evidence in some cancer cells for an increase in resistance to perforin/granzyme B‐mediated cell death by immune cells (Ben Safta et al., 2015), reduction in cell surface MHC class I‐related chain (MIC) proteins, MICA and MICB, and UL16 binding proteins, ligands for NK‐activating receptor‐activating NKG2D (Malladi et al., 2016).