In this prospective study, we found that IL-33 and ST2 levels increased with increasing stage of CKD in patients with chronic renal failure and IL-33, ST2, hs-CRP, diabetes and smoking history, proteinuria and Hb level were associated with vascular dysfunction and were also a predictor of fatal–nonfatal cardiovascular events and survival. The gene discussed is GSTM1; the disease is diabetes mellitus.