Depletion of CD11b+ DC was similar with DT or CLL treatment (Fig 6F) and, although DT treatment reduced the number of neutrophils, the permissive CLL treatment actually increased numbers of these cells (Fig 6C), which supported our observation that systemic depletion of these cells with anti-Ly6G antibody did not allow systemic spread of VACV (Fig 3D). This evidence concerns the gene ITGAM and B-cell chronic lymphocytic leukemia.