CD8A and B-cell chronic lymphocytic leukemia: However, although systemic CLL treatment did partially deplete D-LN macrophages (Fig 4A), Ly6C++ monocytes (Fig 4B), and CD8+ DC (Fig 4D) populations to a statistically significant degree, the depletion was never greater than 50%, i.e. DT was much more effective at depleting these populations than CLL.