ERLIN2 and infection: To verify that this decreased infection is indeed caused by the knockdown of Erlin1 and Erlin2 and not due to unexpected off-target effects, we employed a rescue experiment by transfecting siRNA-resistant FLAG-tagged Erlin1 (Erlin1*-FLAG), Erlin2 (Erlin2*-FLAG), or the control GFP-FLAG construct in cells simultaneously depleted of Erlin1/2.