ITPR3 and cancer: PDT-induced Ca2+ mobilization was significantly reduced when PTEN or IP3R3 were depleted, and, compared to cell lines expressing PTEN and high levels of IP3R3, cancer cell lines expressing no or low levels of PTEN and low levels of IP3R3 displayed less Ca2+ mobilization and less apoptotic markers upon photodynamic therapy (PDT) treatment (Extended Data Fig. 7a, b).