As for the anti-cancer activity, YC-1 can repress the proliferation of various types of cancer cells, including head and neck squamous cell carcinoma [48], esophageal squamous carcinoma [43], lung cancer [61–65], lymphoma [66, 67], bladder cancer [41, 68], hepatocellular carcinoma [52, 69], breast cancer [35, 55, 70], neuroblastoma [32], ovarian carcinoma [71], prostate cancer [72], pancreatic cancer [73], renal carcinoma [56, 74, 75], osteosarcoma [45], colon cancer [76, 77] and leukemia [20, 39, 49, 78]. The gene discussed is RBMS1; the disease is cancer.