Recently identified mutations and variants in genes encoding important immune receptors including CD33, CR3 (Complement Receptor 3), and TREM2 (Triggering Receptor Expressed On Myeloid Cells 2), have been genetically linked to LOAD risk, highlighting the potential role of a dysregulated immune response in an early, and perhaps causative role in AD pathogenesis. This evidence concerns the gene CRIPTO3 and Alzheimer disease.