These include LOAD risk-associated gene Cathepsin D (FDR = 4.9E−02) [16, 70, 72], and Akt1 (FDR = 6.8E−04), a molecule that is activated in LOAD [65] and is associated with LOAD risk in Chinese Han AD patients with type 2 diabetes [50]. Here, CTSD is linked to type 2 diabetes mellitus.