PSEN1 and Alzheimer disease: Although we did not observe enrichments in APP/PSEN1;Tyrobp−/−, we found that the DEG down-regulated in PC of APP/PSEN1;Tyrobp+/− (FDR <0.2) were enriched for several sub-networks from both the MSBB and the HBB AD cohorts, including insulin-like growth factor binding, skeletal development, immune system process, anion transport, and particularly the extracellular matrix (see Suppl.6).