STAT1 and experimental autoimmune encephalomyelitis: IL-27 can also exert anti-inflammatory effects, through inhibiting the generation of T cells into its subset Th17 via signal transducer and activator of transcription 1 (STAT1) and STAT3 signaling pathways, thus alleviating the symptoms of experimental autoimmune encephalomyelitis (EAE) [1, 8].