APOE and obesity due to melanocortin 4 receptor deficiency: Interestingly, APOE4 carriers can be more sensitive to metabolic consequences associated with obesity (de-Andrade et al., 2000; Kypreos et al., 2009; Niu et al., 2009; Atabek et al., 2012; Zarkesh et al., 2012; Guan et al., 2013).