Obesity is strongly associated with development of impaired glucose and insulin metabolism (Kahn et al., 2006; Singla et al., 2010), which are also characteristic of AD patients and have been proposed as possible mechanisms driving AD pathogenesis (Craft, 2005; Martins et al., 2006; Craft, 2009). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.