APOE and Alzheimer disease: Similarly, our findings replicate prior rodent data (Fryer et al., 2005; Castellano et al., 2011; Youmans et al., 2012; Rodriguez et al., 2014; Cacciottolo et al., 2016) that model the human observation that APOE4 increases the risk and or accelerates the onset of AD pathology (Corder et al., 1993; Saunders et al., 1993; Strittmatter et al., 1993; Morris et al., 2010; Jack et al., 2015).