Hyperactive PI3K/Akt/mTOR signaling has been well characterized in epilepsy-associated memory deficits (Ehninger et al., 2008; Brewster et al., 2013; Cambiaghi et al., 2013; Trinh and Klann, 2013; Lugo et al., 2014). Here, AKT1 is linked to epilepsy.