We have recently identified the presence of cathepsin B, a lysosomal cysteine protease that catalyses the conversion of pro-renin into active rennin (27, 28), cathepsin D, an aspartic lysosomal protease bearing significant homology to renin thus engages in renin-like actions of converting AGN to ATI (29, 30), and cathepsin G, a serine protease with the capacity to generate ATII from ATI and directly from AGN (31, 33), within proliferating infantile hemangioma (IH) (34). This evidence concerns the gene CTSB and capillary hemangioma.