Overall, genes affected by potential somatic variants in OCCCs in the present study included KMT2D, KRAS, ARID1A, PIK3CA, TP53, ERBB2, NOTCH1, and SPOP. These genes, spanning variants over 8/10 tumors, are associated with a comprehensive list of functions that relate to multiple cancer driving cellular processes. Here, SPOP is linked to cancer.