Moreover, pre- and postexposure to high altitude, a change in the interleukin genes occurred in individuals with AMS, with downregulation of IL2, IL4, IL6ST, IL7, IL7R, IL10, IL17B, IL32, and IL23R and upregulation of IL13 and IL17F. The results indicated that inflammatory and immune responses are important pathophysiological processes in AMS. Here, IL6ST is linked to ablepharon macrostomia syndrome.