MYD88 and experimental autoimmune encephalomyelitis: We previously reported that TLR2 and TLR4 alone did not significantly contribute to experimental autoimmune encephalomyelitis (EAE), however MyD88 was required for EAE induction by active immunization with myelin antigen in Complete Freund’s Adjuvant (CFA); MyD88-deficient mice immunized with MOG35-55 developed a population of IL-10-producing T cells that prevented EAE induced by adoptive transfer of encephalitogenic T cells.