Seropositivity against GroEL, a protein pertaining to the group of chaperons that has been related to gastric and CRC in some previous studies (Gao et al., 2009; Epplein et al., 2013; Murphy et al., 2015), was associated with an increased CRC risk in infected subjects in our sample when adjusting by serostatus against other proteins. This evidence concerns the gene HSPD1 and colorectal carcinoma.