Decompensated hypertrophy results in pathological hypertrophy and heart failure, which involves the activation of NFAT signaling, β-AR-CaMKII signaling, cGMP-PKG signaling, and PKC-MAPKs signaling (Bernardo et al., 2010; Shimizu and Minamino, 2016). The gene discussed is PRRT2; the disease is heart failure.