Interestingly, this inhibition only occurred in cetuximab-sensitive but not in cetuximab-resistant HNSCC cell lines, data that argues in favor of a metabolic immunoescape mechanism to EGFR inhibition of HNSCC cells mediated by lactate acidification of the tumor milieu (Lu et al., 2013). Here, EGFR is linked to head and neck squamous cell carcinoma.