EGFR and non-small cell lung carcinoma: In addition to overexpression of wild type EGFR, some tumors also exhibit activating mutant forms such as glioblastoma, where a variant called EGFRvIII has been reported (Gan et al., 2013) or non-small cell lung cancer (NSCLC) where mutations in the gene encoding the EGFR kinase domain (T790M) have been associated with tumor resistance (Ohashi et al., 2013).