Notably, there appears to be a crosstalk between EGFR and IFNγ pathways regarding PD-L1 regulation at least in HNSCC, since EGFR blockade downregulated IFNγ-dependent PD-L1 expression (Concha-Benavente et al., 2016). Here, EGFR is linked to head and neck squamous cell carcinoma.