In addition to enhancing NK mediated cytotoxicity which is likely its most conspicuous effect, it has been recently shown that it could also activate neutrophils and mediate ADCC against EGFR expressing tumor cells via interaction with FcγRIIa, interestingly, this cytotoxic effect was FcγRIIIa genotype-dependent (Trivedi et al., 2016). Here, EGFR is linked to neoplasm.