In this setting, one of the most studied oncogenic signaling pathways that has been characterized in many types of cancer is the ErbB/Her family of growth factor receptors that belong to the super family of receptor tyrosine kinases (RTK), given their capacity of phosphorylating tyrosine resides in their cytoplasmic tail and transduce extracellular signals through the activation of intracellular messengers (Linggi and Carpenter, 2006). The gene discussed is EGFR; the disease is cancer.