In this review we will discuss how tumor cell intrinsic oncogenic signals downstream the EGFR can lead to immunoescape by downregulating tumor cell immunogenicity such as diminishing HLA class I mediated antigen presentation or providing inhibitory signals, such as checkpoint inhibition mediated by programmed death ligand 1 (PD-L1), suppressive cytokines that induce an exhausted phenotype or modifying the extracellular milieu by upregulating concentrations of lactate. This evidence concerns the gene CD274 and neoplasm.