EGFR and neoplasm: Therefore, EGFR blockade may not only diminish the tumor cell intrinsic EGFR-induced PD-L1 upregulation but also the cell extrinsic IFNγ-mediated signals that have been associated with CD8+ T cell infiltration in the TME (Lyford-Pike et al., 2013; Topalian et al., 2015).