CD274 and melanoma: Supporting these results is the recent finding by Zaretsky et al. where JAK2 inactivating mutations correlated with resistance to anti-PD-1 therapy in melanoma patients, in this setting we could speculate that tumor cells are sculpted by the immune system developing new strategies to evade anti-PD-L1/PD-1 pathway blocking therapy by downregulating JAK2-mediated expression of PD-L1 (Zaretsky et al., 2016).