In the tumor microenvironment, the presence of suppressive cytokines promotes unresponsiveness of CD8+ T effector immune cell infiltrates and proliferation of suppressive cell subsets such as regulatory T cells (Treg), myeloid derived suppressive cells (MDSC) or tumor-associated macrophages (TAM) (Rabinovich et al., 2007; Burkholder et al., 2014). This evidence concerns the gene CD8A and neoplasm.