Interestingly, it has also been reported that cetuximab-mediated EGFR blockade induced Treg expansion in head and neck cancer patients which correlated with resistance to cetuximab therapy (Jie et al., 2015), such Treg expansion was induced partially by DC maturation and T cell receptor stimulation in the presence of TGFβ. This evidence concerns the gene EGFR and head and neck cancer.