IL18 and renal fibrosis: This renal injury and fibrosis can be blocked with MRA treatment and is reduced in mice lacking galectin-3 (Calvier et al., 2015), PAI-1 (Ma et al., 2006), interleukin-18 (IL-18) (Tanino et al., 2016), or inflammasome activation in macrophages (Kadoya et al., 2015), suggesting their involvement in the MR-mediated renal fibrosis.