CCN2 and kidney disorder: Analysis of tissues from acute and chronic animal models of kidney disease have shown that MRAs suppress the development of glomerulosclerosis and interstitial fibrosis, which is usually linked to reduced production or deposition of matrix proteins (e.g., collagen, fibronectin) and profibrotic molecules (e.g., TGF-β1, plasminogen activator inhibitor-1 [PAI-1], connective tissue growth factor [CTGF]) (Trachtman et al., 2004; Kang et al., 2009; Sun et al., 2015).