Contractile and relaxation responses are MR-dependent and require MR signaling in both cells types, whereas cell-selective deletion studies of the MR shows that VSMC MR but not endothelial cell MR are required for age-related and other forms of hypertension (McCurley and Jaffe, 2012; Rickard et al., 2014). This evidence concerns the gene NR3C2 and Hypertension.