APOE and endothelial dysfunction: This therapeutic action has been demonstrated in ApoE-deficient mice exposed to a lipid-rich Western-type diet (WD) (Nakashima et al., 1994), which even on a normal diet (ND) exhibit endothelial dysfunction (Plump et al., 1992; Bonthu et al., 1997; Barton et al., 1998; d'Uscio et al., 2001) proposed to initiate atherogenesis (Libby and Galis, 1995; Libby et al., 1995; Barton and Haudenschild, 2001).