LRRK2 and Parkinson disease: Of note, RGS2 protected against neuronal toxicity in a Caenorhabditis elegans model expressing wild type LRRK2. Combination of -omics data from different tissues, for example brain and blood, may be advantageous to understand neurodegeneration in light of the recent finding that demonstrated that cell types outside the brain contain genetic risk factors associated with PD (Coetzee et al., 2016) and thus may help uncover new putative therapeutic targets.