LEF1 and Alzheimer disease: Among these genes, there were important transcription factors and kinases associated with AD including LEF1, SOX9, YY1, TCF3, TFDP1, CDK5, CSK and MAP3K3. Among these genes, overactivation of CDK5 is a major trigger of tau hyperphosphorylation and NFT formation in AD suggesting it may be a target for therapeutic intervention (Wilkaniec et al., 2016).