In 2013, a large number of heterozygous mutations were identified in the GRIN2A gene, which encodes the GluN2A subunit of NMDARs, in patients and families with disorders of the epilepsy-aphasia spectrum (EAS; Carvill et al., 2013; Lemke et al., 2013; Lesca et al., 2013). This evidence concerns the gene GRIN2A and epilepsy.