MTOR and major depressive disorder: In contrast, extended use of the inactive arm would induce constitutive expression of Kv1.1, 1.2, β2, and Lgi1 that could lead to dangerously low mTOR activity and diseases with hypoactive mTOR (e.g., Parkinson’s disease, Rett’s syndrome, and major depressive disorder; Karege et al., 2007; Swiech et al., 2008; Taneja et al., 2009; Bové et al., 2011; Jernigan et al., 2011; Ricciardi et al., 2011; Chandran et al., 2013; Figure 1B).