C9orf72 and amyotrophic lateral sclerosis: Consistently, experiments performed on ALS patient samples, neuronal cell lines (N2a, SH-SY5Y) and primary neuronal cell cultures indicated that the C9orf72 protein co-localizes and interacts with RAB1, RAB5, RAB7, and RAB11, which are involved in autophagy (Farg et al., 2014).