Additionally, mutations in the protein charged multivesicular body protein 2B (CHMP2B) affecting the activity of the endosomal sorting complex required for transport (ESCRT) have been identified in ALS and FTLD which prevent the formation of the amphisomes, the vesicles that arise from the fusion of the autophagosome with the endosome and ultimately fuse with the lysosome. This evidence concerns the gene CHMP2B and amyotrophic lateral sclerosis.