In line with this study, Barmada et al. screened over a million of compounds and found that pluphenazine-, methontrimeprazine- and compound 10-(4′-(N-diethylamino)butyl)-2- chlorophenoxazine are able to induce autophagy, enhance the turnover of TDP-43 WT and TDP-43 A315T, and increase the survival of neurons in ALS models (Barmada et al., 2014). Here, TARDBP is linked to amyotrophic lateral sclerosis.