PPARGC1A and early-onset autosomal dominant Alzheimer disease: Studies have revealed possible connections between PGC-1α and several neurodegenerative diseases (Rona-Voros and Weydt, 2010; Tsunemi and La Spada, 2012), including Huntington’s disease (HD; Cui et al., 2006), amyotrophic lateral sclerosis (ALS; Zhao et al., 2011), Alzheimer’s disease (AD; Sheng et al., 2012) and PD (Shin et al., 2011).