In the PD model groups, upon silencing the PGC-1α gene, NRF-1 protein expression decreased by 69.39% (P < 0.05), and compared with the Ad+MPP+ groups, NRF-1 protein expression decreased by 36.12% (P < 0.05) in the PGC-1α+MPP+ groups. The gene discussed is PPARGC1A; the disease is Parkinson disease.