SERPINB3 and Cirrhosis: Literature data relating SerpinB3 with advanced cirrhosis and hepatocellular carcinoma have also evidenced that, beside enhancing TGF-β1 expression, SerpinB3 can induce epithelial-mesenchymal transition (EMT) of hepatoma cancer cells, resulting in their increased invasiveness and proliferation12, 17, 19, 21.