The levels of TNF-α, IL-6, and IL-1β in endotoxemia mice treated with N2 (111.9, 630.3, and 33.3 pg/ml, respectively), N6 (127.2, 350.1, and 127.2 pg/ml, respectively) or PMB (74.0, 514.9, and 242.8 pg/ml, respectively) were significantly lower than those of the corresponding LPS-challenged control groups (394.9, 1026.8, and 292.9 pg/ml, respectively). This evidence concerns the gene IL6 and serum lipopolysaccharide activity.