The notion that NRAP deficiency is not pathogenic by itself is consistent with the recent report by D’Avila et al. 17, who described an Italian female patient with myofibrillar myopathy caused by the BAG3:c.626C > T (p.P209L) mutation accompanied by three NRAP nonsynonymous variants (rs200747403 c.3674G > A:p.A1225V, rs2270182 c.1556T > A:p.N519I, rs2275799 c.844C > T:p.A282T) and the FHL1 variant (rs151315725 c.823G > A:p.D275N). This evidence concerns the gene BAG3 and myofibrillar myopathy.