However, TRADD is expressed at high levels in GBM (Glioblastoma multiforme) where it is detected in both the cytoplasm and the nucleus10, and silencing of TRADD in glioma cells resulted in increased sensitivity to TMZ (Temozolomide) by regulating NF-κB, suggesting that cytoplasmic TRADD is a key driver of NF-κB activation in GBM. This evidence concerns the gene TRADD and central nervous system cancer.