However, when we analysed the predicted targets and GO process, we found that miR-1291 (miRNA with unknown role in the testis) had as target DNA methyltransferases (Dnmt3a, Dnmt3b) (Table 3) involved in de novo histone methylation, genomic imprinting, X-chromosome inactivation and testicular germ cell tumours due to exposure to alkylphenols57, 58. This evidence concerns the gene DNMT3B and childhood testicular germ cell tumor.