Interestingly, Cblb-deficient tumor infiltrating antigen presenting cells (CD45+ MHC-II+) expressed significantly more PD-L1 on a per cell basis (not shown) and also the fraction of PD-L1 positive cells was significantly higher (wt: 85.7% ± 1.5%; Cblb−/−: 92.3% ± 1.9%) (p = 0.035; n = 6). The gene discussed is CD274; the disease is neoplasm.