The result of a study using orthotropic implantation mouse model and cDNA microarray analysis indicated that the expression level of RNF125 was significantly different between primary tumors in Stage III colorectal cancer patients with lymph node metastasis and Stage II patients without lymph node metastasis, believing that RNF125 could play an important role in lymph node metastasis of colorectal cancer [18]. Here, RNF125 is linked to colorectal cancer.