After 3 days of lentiviruses infection shRNA, the invasive cells per field of NOZ cells were significantly reduced following RNF125 knockdown (Figure 4A; **P = 0.000); and, the adhesion rate of NOZ cells was significantly increased in shRNF125 as compared to shCtrl (Figure 4B, #P = 0.022). The gene discussed is RNF125; the disease is infection.