EMT converts polarized epithelial cells to motile mesenchymal cells, operates during embryonic cell layer movements and tumor cell invasiveness; and during EMT, the epithelial markers E-cadherin and cytokeratin are downregulated, while the mesenchymal markers N-cadherin, vimentin and α-smooth muscle actin are upregulated [21]. The gene discussed is CDH2; the disease is neoplasm.