And, RNF125 expression was correlated with tumor differentiation (P = 0.017), Nevin stage (P = 0.042), UICC stage (P = 0.021), liver metastasis (P = 0.020) and vascular invasion (P = 0.016), whereas no correlation was observed with gender, age, tumor location, tumor size, histological type, lymph node metastasis and resection type (all P > 0.05; Table 1). Here, RNF125 is linked to metastasis.