Our findings that AML1-ETO also occupies the miR-29a/b-1 locus and transcriptionally regulates its expression suggest that AML1-ETO regulates miR-29a/b-1 locus both directly and indirectly (via regulation of C/EBPα), indicating that a regulatory circuit between AML1-ETO and miR-29b-1 is operative in leukemia cells to drive tumor properties. Here, RUNX1 is linked to leukemia.